Synopsis:

two brothers, alchemy, adventure, science and morals...

When their father leaves and their mother gets sick and dies, edward and his little brother alphonse elric try to bring their mother back to life. It turns into a disaster, Al almost dies, but Ed attaches his soul to a full-body armor, then his leg and arm are take from him. Now he uses automail, made by Winry and her Grandmother. then they try to become really good at alchemy, try to get the philosophers stone, which is supposed to help, to get al's body back and ed's arm and leg...
ed becomes a state alchemist, aka dog of the military so he can get to more research about the stone
the bad guys are homunculi (almost like humans but without much weakness or souls)